Journal: Bioactive Materials
Article Title: Long-term safety and absorption assessment of a novel bioresorbable nitrided iron scaffold in porcine coronary artery
doi: 10.1016/j.bioactmat.2022.01.005
Figure Lengend Snippet: Imaging manifestations of nitrided iron scaffold after implantation. The typical QCA images of a 3.0 × 18 mm nitrided iron scaffold was implanted in porcine right coronary artery: (A) pre-implantation, (B) post-implantation and (C) at 7 years after implantation. The angiography showed that the scaffolded artery had restored to bend shape at 7 year after implantation. (D) Intravascular ultrasound image at 7 years after implantation showed uniform strong echoes in the blood vessel wall, and no ultrasound attenuation was detected. There was no any trail of the struts, indicating the scaffolds were almost completely degraded. Furthermore, each OCT frame represented the observations at different time points, revealing the process of corrosion and absorption of nitrided iron scaffold as well: (E) post implantation, (F) at 4 weeks, all scaffold structure remained complete; (G) at 52 weeks, small part of struts was corroded; (H) at 2.5 years, part of struts was corroded; (I) at 4.5 years, struts were partially corroded; and (J) at 7 years, struts were almost completely corroded and corrosion products were bioabsorbed in situ.
Article Snippet: Intravascular images were acquired using coronary angiography (Allura Xper FD20, Philips Medical Systems, Best, the Netherlands), optical coherence tomographic (OCT) imaging (M2 and C7 XR, Light Lab Imaging, St. Jude Medical, Westford, Massachusetts) and intravascular ultrasound (IVUS) imaging (Boston Scientific Corp/SCIMED, Minneapolis, MN, USA).
Techniques: Imaging, In Situ